The surgical site infections still represent a big concern, which causes prolonged hospital staying, major costs for both healthcare system and professional insurance. In order to fight with the post-surgery infections, one of the emerging needs for the healthcare industry is to use antibacterial coating on surgical instruments. Scientists are continuously looking for the discovery of new antimicrobial agents that remain active in biomedical device coatings which is crucial to fight against the infections. Scientists have been exploring multiple “antibacterial coating materials” which are 1,000 times more effective than current commercial coating.


“Triclosan” which is currently been used as antibacterial coating has many downsides. First of “Triclosan slows the growth of bacteria but doesnot kill the bacteria”. Secondly “Triclosan cam be absorbed in the body, which can possibly cause adverse health effects”.


Scientists are looking at PAMBM, as an alternative to Triclosan. PAMBM is a new substance designed from naturally occurring antimicrobial peptides that can kill a wide range of bacteria. PAMBM has a very low chance of causing bacterial resistance and the emergence of so-called superbugs. Lab tests indicate that PAMBM greatly reduced the amount of bacteria compared to Triclosan. In a head-to-head test with Triclosan-coated sutures, those coated with PAMBM were much more effective against bacteria. “As bacterial resistance to current agents continues to increase and with resistance to Triclosan now documented, the discovery of new antimicrobial agents that remain active in biomedical device coatings is essential,” say the researchers.